Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.

@article{Neilan2007DisruptionON,
  title={Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.},
  author={Tomas G. Neilan and Sarah L Blake and Fumito Ichinose and Michael J. Raher and Emmanuel S Buys and Davinder S Jassal and Elissa Furutani and T. Perez-Sanz and Amanda Graveline and Stefan P. Janssens and Michael H Picard and Marielle Scherrer-Crosbie and Kenneth D. Bloch},
  journal={Circulation},
  year={2007},
  volume={116 5},
  pages={
          506-14
        }
}
BACKGROUND Flavoprotein reductases are involved in the generation of reactive oxygen species by doxorubicin. The objective of the present study was to determine whether or not one flavoprotein reductase, endothelial nitric oxide synthase (nitric oxide synthase 3 [NOS3]), contributes to the cardiac dysfunction and injury seen after the administration of doxorubicin. METHODS AND RESULTS A single dose of doxorubicin (20 mg/kg) was administered to wild-type (WT) mice, NOS3-deficient mice (NOS3… CONTINUE READING

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