Disruption of microRNA-21 by TALEN leads to diminished cell transformation and increased expression of cell-environment interaction genes.

@article{Chen2015DisruptionOM,
  title={Disruption of microRNA-21 by TALEN leads to diminished cell transformation and increased expression of cell-environment interaction genes.},
  author={Buyuan Chen and Xinji Chen and Xiwei Wu and Xiaoling Wang and Yingjia Wang and Ting-Yu Tony Lin and Jessica S Kurata and Jingjing Wu and Steven L. Vonderfecht and Guihua Sun and He Huang and Douglas J. Jolly and Jianda Hu and Ren-Jang Lin},
  journal={Cancer letters},
  year={2015},
  volume={356 2 Pt B},
  pages={
          506-516
        }
}
MicroRNA-21 is dysregulated in many cancers and fibrotic diseases. Since miR-21 suppresses several tumor suppressor and anti-apoptotic genes, it is considered a cancer therapeutic target. Antisense oligonucleotides are commonly used to inhibit a miRNA; however, blocking miRNA function via an antagomir is temporary, often only achieves a partial knock-down, and may be complicated by off-target effects. Here, we used transcription activator-like effector nucleases (TALENs) to disrupt miR-21 in… CONTINUE READING
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