Disruption of metallothionein expression with antisense oligonucleotides abolishes protection against cadmium cytotoxicity in molluscan hemocytes.

@article{Butler2001DisruptionOM,
  title={Disruption of metallothionein expression with antisense oligonucleotides abolishes protection against cadmium cytotoxicity in molluscan hemocytes.},
  author={Rondi A. Butler and Guritno Roesijadi},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={59 1},
  pages={
          101-7
        }
}
The relationship between metallothionein (MT) induction and cytotoxicity was examined in isolated oyster hemocytes exposed in vitro to cadmium, copper, and zinc. In all cases MT induction increased to peak levels with increased metal dose, then declined with continued increases in dose. The effectiveness of these metals as inducers of MT was cadmium > copper > zinc, with cadmium the most effective inducer in magnitude of induction and sensitivity to dose. Cytotoxicity of the metals, based on… CONTINUE READING

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