Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin.

@article{Wittbrodt1994DisruptionOM,
  title={Disruption of mesoderm and axis formation in fish by ectopic expression of activin variants: the role of maternal activin.},
  author={Joachim Wittbrodt and Fr{\'e}d{\'e}ric Marc Rosa},
  journal={Genes & development},
  year={1994},
  volume={8 12},
  pages={1448-62}
}
Formation of mesoderm in Xenopus embryos is the result of an induction event in which peptides such as FGF or activins have been implicated. It was recently demonstrated, by the ectopic expression of a truncated activin receptor, that activin receptor signaling pathways are involved in the processes of mesoderm and axis formation in vivo. However, this approach does not directly address the role of activin itself nor the involvement of activins in the formation of mesoderm in embryos from other… CONTINUE READING

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