Disruption of limbic white matter pathways in mild cognitive impairment and Alzheimer's disease: a DTI/FDG-PET study.

@article{Bozoki2012DisruptionOL,
  title={Disruption of limbic white matter pathways in mild cognitive impairment and Alzheimer's disease: a DTI/FDG-PET study.},
  author={Andrea C. Bozoki and Igor O. Korolev and Nathan C Davis and Lori A. Hoisington and Kevin L Berger},
  journal={Human brain mapping},
  year={2012},
  volume={33 8},
  pages={1792-802}
}
BACKGROUND Alzheimer's disease (AD) and mild cognitive impairment (MCI) affect the limbic system, causing medial temporal lobe (MTL) atrophy and posterior cingulate cortex (PCC) hypometabolism. Additionally, diffusion tensor imaging (DTI) studies have demonstrated that MCI and AD involve alterations in cerebral white matter (WM) integrity. OBJECTIVES To test if (1) patients with MCI and AD exhibit decreases in the integrity of limbic WM pathways; (2) disconnection between PCC and MTL… CONTINUE READING
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