Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.

  title={Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice.},
  author={Tomoaki Morioka and Esra Asilmaz and Jiang Wei Hu and John F. Dishinger and Amarnath J. Kurpad and Carol F Elias and Hui Li and Joel K Elmquist and Robert T Kennedy and Rohit N. Kulkarni},
  journal={The Journal of clinical investigation},
  volume={117 10},
Obesity is characterized by hyperinsulinemia, hyperleptinemia, and an increase in islet volume. While the mechanisms that hasten the onset of diabetes in obese individuals are not known, it is possible that the adipose-derived hormone leptin plays a role. In addition to its central actions, leptin exerts biological effects by acting in peripheral tissues including the endocrine pancreas. To explore the impact of disrupting leptin signaling in the pancreas on beta cell growth and/or function, we… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 93 extracted citations

Role of leptin in the pancreatic β-cell: effects and signaling pathways.

Journal of molecular endocrinology • 2012
View 11 Excerpts
Highly Influenced

The role of leptin in glucose homeostasis

Journal of diabetes investigation • 2012
View 5 Excerpts
Highly Influenced

Quercetin Preserves β-Cell Mass and Function in Fructose-Induced Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation

Evidence-based complementary and alternative medicine : eCAM • 2013
View 5 Excerpts
Highly Influenced

L-lactic acid's improvement of swimming endurance in mice.

International journal of sport nutrition and exercise metabolism • 2009
View 2 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 42 references

Role of VEGF-A in Vascularization of Pancreatic Islets

Current Biology • 2003
View 4 Excerpts
Highly Influenced

The adipoinsular axis: effects of leptin on pancreatic beta-cells.

American journal of physiology. Endocrinology and metabolism • 2000
View 6 Excerpts
Highly Influenced

Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance.

Proceedings of the National Academy of Sciences of the United States of America • 2007
View 1 Excerpt

Similar Papers

Loading similar papers…