Disruption of lens fiber cell differentiation and survival at multiple stages by region-specific expression of truncated FGF receptors.

@article{Stolen2000DisruptionOL,
  title={Disruption of lens fiber cell differentiation and survival at multiple stages by region-specific expression of truncated FGF receptors.},
  author={Craig M Stolen and Anne E. Griep},
  journal={Developmental biology},
  year={2000},
  volume={217 2},
  pages={205-20}
}
To determine if fibroblast growth factor signaling mechanisms are required for terminal differentiation and survival of lens fiber cells, we evaluated the effects of expressing truncated fibroblast growth factor receptors (tFGFRs) in different regions of the developing lens. Two sets of transgenic mice were generated, one expressing tFGFRs from the alphaA-crystallin promoter (alphaA-tFGFR), which expresses linked genes in fiber cells throughout their differentiation program, and the other… CONTINUE READING

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