Disruption of layers 3 and 4 during development results in altered thalamocortical projections in ferret somatosensory cortex.

@article{Noctor2001DisruptionOL,
  title={Disruption of layers 3 and 4 during development results in altered thalamocortical projections in ferret somatosensory cortex.},
  author={Stephen Charles Noctor and Sidney L Palmer and Debra F. McLaughlin and Sharon L. Juliano},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 9},
  pages={3184-95}
}
The precision of projections from dorsal thalamus to neocortex are key toward understanding overall cortical organization and function. To identify the significance of layer 4 cells in receiving the bulk of thalamic projections in somatosensory cortex, we disrupted layer 4 genesis and studied the effect on thalamic terminations in ferrets. Second, we ascertained the result of layer 4 disruption on functional responses and topographic organization. Methylazoxy methanol (MAM) was injected into… CONTINUE READING
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