Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells.

@article{Stein1998DisruptionOI,
  title={Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells.},
  author={J Stein and J Ries and K E Barrett},
  journal={The American journal of physiology},
  year={1998},
  volume={274 1 Pt 1},
  pages={G203-9}
}
  • J Stein, J Ries, K E Barrett
  • Published 1998 in The American journal of physiology
The objective was to characterize changes in barrier and transport function in an experimental model of colitis, and to determine whether mast cells contribute to these changes. Colitis was induced in rats with intracolonic 2,4,6-trinitrobenzenesulfonic acid (TNBS, 30 mg) in 50% ethanol. Controls received 0.9% saline or the ethanol vehicle alone. In vivo loop perfusion was used to assess colonic water flux (in microliter.cm-1.h-1) and lumen-to-blood 51Cr-labeled EDTA clearance (% administered… CONTINUE READING