Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness.

@article{Tse2007DisruptionOI,
  title={Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness.},
  author={Hubert M Tse and Martha J. Milton and Sheila Schreiner and Jennifer L Profozich and Massimo Trucco and Jon D Piganelli},
  journal={Journal of immunology},
  year={2007},
  volume={178 2},
  pages={908-17}
}
Successful Ag activation of naive T helper cells requires at least two signals consisting of TCR and CD28 on the T cell interacting with MHC II and CD80/CD86, respectively, on APCs. Recent evidence demonstrates that a third signal consisting of proinflammatory cytokines and reactive oxygen species (ROS) produced by the innate immune response is important in arming the adaptive immune response. In an effort to curtail the generation of an Ag-specific T cell response, we targeted the synthesis of… CONTINUE READING
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