Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis.

Abstract

RATIONALE Isoforms I and II of the glycolytic enzyme hexokinase (HKI and HKII) are known to associate with mitochondria. It is unknown whether mitochondria-bound hexokinase is mandatory for ischemic preconditioning and normal functioning of the intact, beating heart. OBJECTIVE We hypothesized that reducing mitochondrial hexokinase would abrogate ischemic… (More)
DOI: 10.1161/CIRCRESAHA.111.244962

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@article{Smeele2011DisruptionOH, title={Disruption of hexokinase II-mitochondrial binding blocks ischemic preconditioning and causes rapid cardiac necrosis.}, author={Kirsten M.A. Smeele and Richard Southworth and Rongxue Wu and Chaoqin Xie and Rianne Nederlof and Alice Warley and Jessica Nelson and Pepijn van Horssen and Jeroen P H M van den Wijngaard and Sami Heikkinen and M. Laakso and Anneke Koeman and Maria Siebes and Otto Eerbeek and Fadi Gabriel Akar and Hossein Ardehali and M W Hollmann and Coert J Zuurbier}, journal={Circulation research}, year={2011}, volume={108 10}, pages={1165-9} }