Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.

@article{Reijmers2011DisruptionOH,
  title={Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.},
  author={Rogier M Reijmers and Richard W. J. Groen and Annemieke J Kuil and Kees C Weijer and Fiona C. Kimberley and Jan Paul Medema and Toin H van Kuppevelt and Jin-Ping Li and Marcel Spaargaren and Steven T. Pals},
  journal={Blood},
  year={2011},
  volume={117 23},
  pages={
          6162-71
        }
}
The development and antigen-dependent differentiation of B lymphocytes are orchestrated by an array of growth factors, cytokines, and chemokines that require tight spatiotemporal regulation. Heparan sulfate proteoglycans specifically bind and regulate the bioavailability of soluble protein ligands, but their role in the immune system has remained largely unexplored. Modification of heparan sulfate by glucuronyl C5-epimerase (Glce) controls heparan sulfate-chain flexibility and thereby affects… CONTINUE READING

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