Disruption of glucagon-like peptide 1 signaling in Sim1 neurons reduces physiological and behavioral reactivity to acute and chronic stress.

@article{Ghosal2016DisruptionOG,
  title={Disruption of glucagon-like peptide 1 signaling in Sim1 neurons reduces physiological and behavioral reactivity to acute and chronic stress.},
  author={Sriparna Ghosal and Amy E B Packard and Parinaz Mahbod and Jessica M. McKlveen and Randy J Seeley and Brent A. Myers and Yvonne M. Ulrich-Lai and Eric L. P. Smith and David A D'Alessio and James P Herman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016}
}
Organismal stress initiates a tightly orchestrated set of responses involving complex physiological and neurocognitive systems. Here, we present evidence for glucagon-like peptide 1 (GLP-1) mediated paraventricular hypothalamic circuit coordinating the global stress response. The GLP-1 receptor (Glp1r) in mice was knocked down in neurons expressing single-minded 1 (Sim1), a transcription factor abundantly expressed in the paraventricular nucleus (PVN) of the hypothalamus. Mice with Sim1… CONTINUE READING
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