Disruption of gap junctions in toxicity and carcinogenicity.

  title={Disruption of gap junctions in toxicity and carcinogenicity.},
  author={James Kevin Chipman and Angela Mally and Gareth Owain Edwards},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={71 2},
Although the specific role of connexin-mediated gap junctional intercellular communication in the control of cell homeostasis, proliferation, and death are still not clear, several lines of evidence support these roles. The disturbance of this communication, through multiple mechanisms, may in the short term be a protective mechanism to limit the spread of toxicity in a tissue following chemical or radiation damage. However, sustained downregulation confers a loss of tumor-suppressive action… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 42 extracted citations


Publications referenced by this paper.
Showing 1-10 of 85 references

Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from -particle irradiated to nonirradiated cells

E. I. Azzam, S. M. de Toledo, J. B. Little
Proc. Natl. Acad. Sci. U.S.A • 2001
View 2 Excerpts
Highly Influenced

Induction of a bystander mutagenic effect of alpha particles in mammalian cells.

Proceedings of the National Academy of Sciences of the United States of America • 2000
View 2 Excerpts
Highly Influenced

Role of connexin (gap junction) genes in cell growth control and carcinogenesis.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie • 1999
View 4 Excerpts
Highly Influenced

Cell-cell communication in carcinogenesis.

Frontiers in bioscience : a journal and virtual library • 1998
View 5 Excerpts
Highly Influenced

Assessing the effect of ionizing radiation on a gap junction-mediated component of the “bystander effect.

G. O. Edwards, R. Meldrum, C. W. Wharton, S. W. Botchway, J. K. Chipman
Proceedings British Toxicology Society Meeting, • 2002
View 1 Excerpt

Intercellular communication and human prostate carcinogenesis.

Annals of the New York Academy of Sciences • 2002
View 1 Excerpt

Modulation of gap junctional communication by “epigenetic” toxicants: A shared mechanism in teratogenesis, carcinogenesis, atherogenesis, immunomodulation, reproductive- and neurotoxicities

J. E. Trosko, C. C. Chang, B. Upham
Biomarkers of Environmental Associated Disease • 2002
View 2 Excerpts

Similar Papers

Loading similar papers…