Disruption of gap junctions in toxicity and carcinogenicity.

@article{Chipman2003DisruptionOG,
  title={Disruption of gap junctions in toxicity and carcinogenicity.},
  author={James Kevin Chipman and Angela Mally and Gareth Owain Edwards},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2003},
  volume={71 2},
  pages={146-53}
}
Although the specific role of connexin-mediated gap junctional intercellular communication in the control of cell homeostasis, proliferation, and death are still not clear, several lines of evidence support these roles. The disturbance of this communication, through multiple mechanisms, may in the short term be a protective mechanism to limit the spread of toxicity in a tissue following chemical or radiation damage. However, sustained downregulation confers a loss of tumor-suppressive action… CONTINUE READING

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