Disruption of excitatory amino acid transporters in brains of SIV-infected rhesus macaques is associated with microglia activation.

@article{Meisner2008DisruptionOE,
  title={Disruption of excitatory amino acid transporters in brains of SIV-infected rhesus macaques is associated with microglia activation.},
  author={Falko Meisner and Eva Neuen-Jacob and Sieghart Sopper and Michaela Schmidt and Serge Schlammes and Carsten Scheller and Daniel Vosswinkel and Volker ter Meulen and Peter Franz Riederer and Eleni Koutsilieri},
  journal={Journal of neurochemistry},
  year={2008},
  volume={104 1},
  pages={202-9}
}
Glutamate-mediated neurodysfunction in human immunodeficiency virus (HIV) infection has been primarily suggested by in vitro studies. The regulation of glutamatergic neurotransmission in inflammation is a complex interaction between activation of immune mediators and adaptive changes in the functional elements of the glutamatergic synapse. We have used simian immunodeficiency virus (SIV)-infected macaques to answer the questions (i) whether perturbation of glutamate neurotransmission is evident… CONTINUE READING