Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons.

@article{Gamble2005DisruptionOE,
  title={Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons.},
  author={John A Gamble and Delicia K Karunadasa and J R Pape and Michael J Skynner and Martin G. Todman and Robert Bicknell and Jeremy P. Allen and Allan E Herbison},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 12},
  pages={3142-50}
}
Ephrin signaling is involved in repulsive and attractive interactions mediating axon guidance and cell-boundary formation in the developing nervous system. As a result of a fortuitous transgene integration event, we have identified here a potential role for EphA5 in the axophilic migration of gonadotropin-releasing hormone (GnRH) neurons from the nasal placode into the brain along ephrin-expressing vomeronasal axons. Transgene integration in the GNR23 mouse line resulted in a 26 kb deletion in… CONTINUE READING
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