Disruption of endothelial caveolae is associated with impairment of both NO- as well as EDHF in acetylcholine-induced relaxation depending on their relative contribution in different vascular beds.

@article{Xu2007DisruptionOE,
  title={Disruption of endothelial caveolae is associated with impairment of both NO- as well as EDHF in acetylcholine-induced relaxation depending on their relative contribution in different vascular beds.},
  author={Ying Xu and Robert H. Henning and Johannes J L van der Want and Azuwerus van Buiten and Wiek H van Gilst and Hendrik J Buikema},
  journal={Life sciences},
  year={2007},
  volume={80 18},
  pages={1678-85}
}
Caveolae represent an important structural element involved in endothelial signal-transduction. The present study was designed to investigate the role of caveolae in endothelium-dependent relaxation of different vascular beds. Caveolae were disrupted by cholesterol depletion with filipin (4x10(-6) g L(-1)) or methyl-beta-cyclodextrin (MCD; 1x10(-3) mol L(-1)) and the effect on endothelium-dependent relaxation was studied in rat aorta, small renal arteries and mesenteric arteries in the absence… CONTINUE READING
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