Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice

Abstract

Dopamine D1 receptors (D1Rs) play a key role in cocaine addiction, and multiple protein kinases such as GRKs, PKA, and PKC are involved in their phosphorylation. Recently, we reported that protein kinase D1 phosphorylates the D1R at S421 and promotes its membrane localization. Moreover, this phosphorylation of S421 is required for cocaineinduced behaviors… (More)
DOI: 10.1007/s12264-014-1473-9

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@article{Zhang2014DisruptionOD, title={Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice}, author={Ying Zhang and Ning Wang and Ping Su and Jie Lu and Yun Wang}, journal={Neuroscience Bulletin}, year={2014}, volume={30}, pages={1025-1035} }