Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse.

@article{Nilsson2012DisruptionOC,
  title={Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3 in response to bilateral ureteral obstruction in the mouse.},
  author={Line Lynge Nilsson and Kirsten Madsen and Sukru Oguzkan Topcu and Boye Lagerbon Jensen and J\orgen Fr\oki{\ae}r and Rikke N\orregaard},
  journal={American journal of physiology. Renal physiology},
  year={2012},
  volume={302 11},
  pages={F1430-9}
}
Bilateral ureteral obstruction (BUO) in rats is associated with increased cyclooxygenase type 2 (COX-2) expression, and selective COX-2 inhibition prevents downregulation of aquaporins (AQPs) in response to BUO. It was hypothesized that a murine model would display similar changes in renal COX-2 and AQPs upon BUO and that targeted disruption of COX-2… CONTINUE READING