Disruption of contact lens-associated Pseudomonas aeruginosa biofilms formed in the presence of neutrophils.

Abstract

PURPOSE To evaluate the capacity of neutrophils to enhance biofilm formation on contact lenses by an infectious Pseudomonas aeruginosa (PA) corneal isolate. Agents that target F-actin and DNA were tested as a therapeutic strategy for disrupting biofilms formed in the setting of neutrophils in vitro and for limiting the infectious bioburden in vivo… (More)
DOI: 10.1167/iovs.10-6469

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