Disruption of colonic electrolyte transport in experimental colitis.

  title={Disruption of colonic electrolyte transport in experimental colitis.},
  author={Cameron J. Bell and Dietrich Gall and John L Wallace},
  journal={The American journal of physiology},
  volume={268 4 Pt 1},
The time course of disturbances of distal colonic electrolyte transport during experimental colitis in rats was compared with changes in the severity of inflammation and epithelial disruption. Colitis was induced by intracolonic administration of trinitrobenzenesulfonic acid (TNBS). At time points from 1 day to 8 wk thereafter, Na+ and Cl- transport was studied under short-circuited conditions in Ussing chambers, three indexes of tissue inflammation were measured, and histology was performed… CONTINUE READING