Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells.

@article{Beltinger2008DisruptionOC,
  title={Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells.},
  author={Johannes Beltinger and Jo del Buono and Maeve M Skelly and John Thornley and Robin C Spiller and William A Stack and Christopher John Hawkey},
  journal={World journal of gastroenterology},
  year={2008},
  volume={14 48},
  pages={7345-52}
}
AIM To study the mechanisms by which Campylobacter jejuni (C. jejuni) causes inflammation and diarrhea. In particular, direct interactions with intestinal epithelial cells and effects on barrier function are poorly under-stood. METHODS To model the initial pathogenic effects of C. jejuni on intestinal epithelium, polarized human colonic HCA-7 monolayers were grown on permeabilized filters and infected apically with clinical isolates of C. jejuni. Integrity of the monolayer was monitored by… CONTINUE READING

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