Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens

@article{Zito1985DisruptionOC,
  title={Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens},
  author={Kathy A. Zito and Geoffrey Sir Vickers and David C. S. Roberts},
  journal={Pharmacology Biochemistry and Behavior},
  year={1985},
  volume={23},
  pages={1029-1036}
}
In previous experiments we have demonstrated that bilateral infusions of 6-hydroxydopamine (6-OHDA) into the nucleus accumbens result in a drastic reduction in the rate of cocaine self-administration. If this effect is due to the destruction of a presynaptic dopaminergic element in this nucleus, then selective removal of the postsynaptic neuron should also disrupt cocaine self-administration. This hypothesis was tested using the neurotoxin kainic acid. Bilateral kainic acid infusions into the… CONTINUE READING
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