Disruption of circadian rhythms in synaptic activity of the suprachiasmatic nuclei by African trypanosomes and cytokines.

@article{Lundkvist2002DisruptionOC,
  title={Disruption of circadian rhythms in synaptic activity of the suprachiasmatic nuclei by African trypanosomes and cytokines.},
  author={Gabriella Lundkvist and Russell H. Hill and Krister Kristensson},
  journal={Neurobiology of disease},
  year={2002},
  volume={11 1},
  pages={20-7}
}
Disturbances in biological rhythms pose a major disease problem, not the least in the aging population. Experimental sleeping sickness, caused by Trypanosoma brucei brucei, in rats constitutes a unique and robust chronic model for studying mechanisms of such disturbances. The spontaneous postsynaptic activity was recorded in slice preparations of the suprachiasmatic nuclei (SCN), which contain the master pacemaker for circadian rhythms in mammals, from trypanosome-infected rats. The excitatory… CONTINUE READING
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