Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease

@article{Shanmugam2013DisruptionOC,
  title={Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease},
  author={Vignesh Shanmugam and Amro Wagih Wafi and Nawaf Al-Taweel and Dietrich B{\"u}sselberg},
  journal={Journal of local and global health science},
  year={2013},
  volume={2013},
  pages={3}
}
Abstract Incidents of non-communicable diseases (NCD) like cardiovascular diseases, cancer, diabetes, and chronic respiratory disease have increased dramatically and are currently the leading causes of death worldwide. Their rising incidents coincide with the dramatic changes in industrialization and development of societies over the past few hundred years. Therefore, current lifestyle practices should be further explored to uncover novel risk factors for certain cancers (i.e. colon, prostate… 
View via Publisher
qscience.com
36 Citations
Highly Influential Citations
4
Background Citations
18

Figures from this paper

36 Citations

Recent advances in modulators of circadian rhythms: an update and perspective

This work attempts to update the disclosures about the modulators targeting core clock proteins and related post-modification targets, as well as the relationship between circadian rhythm disorders and human health, and the therapeutic role and prospect of these small molecule modulators in circadian rhythm related disease.

Does Circadian Rhythm and Environment Factor Affect the Risk of Breast Cancer? A New Evidence from Kediri, East Java

The risk of breast cancer increased with irregular shift work schedule, sleep duration <5 hours, room light, warm room temperature, air pollution, and chemical exposure.

Circadian Rhythms, Exercise, and Cardiovascular Health

The effects exercise has on the regulation of circadian rhythmicity, specifically with respect to CVD risk factors – including hormonal levels, sleep/wake cycles, blood pressure, and heart rate are discussed.

Circadian rhythms-related disorders in diurnal fat sand rats under modern lifestyle conditions: A review

It is demonstrated that fat sand rats living under the correspondent of “human modern lifestyle” conditions exhibit dampened behavioral and biological rhythms and develop circadian desynchrony, which leads to what is named “The Circadian Syndrome”.

Carcinogenic effects of circadian disruption: an epigenetic viewpoint

The carcinogenic effects of circadian disruption is explained and its potential role in different human cancers using an epigenetic viewpoint is highlighted and the importance of chronotherapy in cancer treatment is highlighted.

Temporal tuning of daily rhythms helps advanced cancer patients and cancer survivors feel better, live better, and live longer

A suite of noninvasive, riskless and costless, largely behavior-based circadian rhythm entrainment and disturbance avoidance techniques for widespread everyday use by cancer patients and survivors are implemented together with real-time actigraphic monitoring, continuous electronic feedback, and positive reinforcement of these simple temporal tuning interventions.

The Effects of Circadian Rhythm Disruption towards Metabolic Stress and Mental Health: A Review

This review summarises the findings from several researches on the physiological (metabolic stress) and psychological (cognitive functioning and mental health) impacts of the CR disruption in order to assist people to have a holistic view on the effects of CR to the authors' mind and body.

The tumour suppressing role of the circadian clock

This review summarises the important role the circadian system plays in regulating cellular processes, including the cell cycle, apoptosis, DNA repair, the epithelial‐to‐mesenchymal transition, metabolism and immunity and how its dysregulation has widespread implications and could be a critical player in the development of cancer.

The Effects of Circadian Rhythm Disruption on Mental Health and Physiological Responses among Shift Workers and General Population

The findings showed that circadian rhythm disruption affects mood and cognitive performance, but it does not significantly affect psychological wellbeing and physiological responses.

Analyses of BMAL1 and PER2 Oscillations in a Model of Breast Cancer Progression Reveal Changes With Malignancy

The data support that there are circadian discrepancies between normal and malignant cells, but it is difficult and insufficient to singularly use period evaluations to differentiate them.

244 References

Effects of circadian disruption on the cardiometabolic system

The evidence for circadian control of cardiometabolic functioning, as well its sensitivity to light and melatonin, is reviewed, and potential implication for therapy is discussed.

Molecular clocks, type 2 diabetes and cardiovascular disease

Current knowledge on the topic of disturbance of circadian rhythms through genetic and environmental influences on the molecular clock is pivotal in the pathogenesis of obesity, type 2 diabetes and cardiovascular disease is described.

Does “Clock” Matter in Prostate Cancer?

It is hypothesized that both altered-lighted environments and genetic variations in genes responsible for maintaining circadian rhythms may result in deregulation of clock-associated biological processes, such as androgen expression, and consequently influence an individual's risk of prostate cancer.

Melatonin and circadian biology in human cardiovascular disease

Current knowledge related to the biological role of melatonin and its circadian rhythm in cardiovascular disease is reviewed, revealing that the blood melatonin rhythm has a crucial role in several cardiovascular functions, including daily variations in blood pressure.

Adverse metabolic and cardiovascular consequences of circadian misalignment

The findings demonstrate the adverse cardiometabolic implications of circadian misalignment, as occurs acutely with jet lag and chronically with shift work, on metabolic, autonomic, and endocrine predictors of obesity, diabetes, and cardiovascular risk.

Circadian rhythms in the CNS and peripheral clock disorders: role of the biological clock in cardiovascular diseases.

The results suggest that cardiovascular systems have their own peripheral clocks, and at least in part, they may regulate the circadian oscillation of cardiovascular function directly.

Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters.

  • T. MartinoG. Oudit M. Sole
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2008
It is demonstrated that devastating effects of rhythm disorganization on cardiovascular and renal integrity and that interventions based on circadian principles prevent disease pathology caused by a short-period mutation (tau) of the circadian system in hamsters.

The orphan nuclear receptor Rev-erbα: a transcriptional link between circadian rhythmicity and cardiometabolic disease

Findings identify Rev-erbα as a modulator of cardiovascular risk factors and as a determinant of the circadian regulation of metabolic pathways, which may serve to integrate metabolic and circadian signals.

Shift work: coping with the biological clock.

Exposure to and/or avoidance of bright light at specific times of the 'biological night' is the most important factor in manipulating the circadian system.

Period3 structural variation: a circadian biomarker associated with breast cancer in young women.

Investigating the association between an exonic length variation in a circadian gene, Period3 (Per3), and breast cancer risk using blood samples collected from a recently completed breast cancer case-control study in Connecticut found that the variant Per3 genotype was associated with an increased risk of breast cancer among premenopausal women.
...