Disruption of cell cycle control by human papillomaviruses with special reference to cervical carcinoma.

@article{Southern2000DisruptionOC,
  title={Disruption of cell cycle control by human papillomaviruses with special reference to cervical carcinoma.},
  author={Shirley A. Southern and C Simon Herrington},
  journal={International journal of gynecological cancer : official journal of the International Gynecological Cancer Society},
  year={2000},
  volume={10 4},
  pages={263-274}
}
Human papillomaviruses (HPVs) play a major role in neoplastic transformation of squamous epithelial cells. The viral genome is small in size and only encodes a limited number of proteins, so one of the major functions of the viral proteins is to modulate the function of key cellular proteins involved in cell cycle control and DNA replication. During this process important host cell cycle checkpoints are lost which may lead to the accumulation of genetic abnormalities and eventual malignant… CONTINUE READING

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