Disruption of blood-brain barrier in Alzheimer disease pathogenesis

  title={Disruption of blood-brain barrier in Alzheimer disease pathogenesis},
  author={Sun-Young Kook and Hyun Seok Hong and Minho Moon and Inhee Mook-jung},
  booktitle={Tissue barriers},
Blood-brain barrier (BBB) regulates transport of various molecules and maintains brain homeostasis. Perturbed intracellular Ca(2+) homeostasis and BBB damage have been implicated in the pathogenesis of Alzheimer disease (AD). Although receptor for advanced glycation end products (RAGE) is known to mediate Aβ transcytosis across the BBB, molecular mechanisms underlying Aβ-RAGE interaction-induced BBB alterations are largely unknown. We found enhanced permeability, decreased zonula occludin-1 (ZO… CONTINUE READING