Disruption of bidirectional oocyte-cumulus paracrine signaling during in vitro maturation reduces subsequent mouse oocyte developmental competence.

@article{Yeo2009DisruptionOB,
  title={Disruption of bidirectional oocyte-cumulus paracrine signaling during in vitro maturation reduces subsequent mouse oocyte developmental competence.},
  author={Christine Xueling Yeo and Robert Bruce Gilchrist and Michelle B. Lane},
  journal={Biology of reproduction},
  year={2009},
  volume={80 5},
  pages={
          1072-80
        }
}
Oocyte-cumulus cell bidirectional communication is essential for normal development of the oocyte and cumulus cells (CCs) within the follicle. We showed recently that addition of recombinant growth differentiation factor 9 (GDF9), which signals through the SMAD2/3 pathway, during mouse oocyte in vitro maturation (IVM) increased fetal viability. This study thus aimed to observe the effects of disrupting oocyte-CC bidirectional communication during IVM on oocyte developmental competence and fetal… CONTINUE READING
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