Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.

@article{FlgelKoch2002DisruptionOA,
  title={Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice.},
  author={Cassandra M. Fl{\"u}gel-Koch and Andreas Ohlmann and Joram Piatigorsky and Ernst R Tamm},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2002},
  volume={225 2},
  pages={111-25}
}
Previous experiments showed that transgenic mice expressing a secreted self-activating transforming growth factor (TGF) -beta1 did not show a phenotype in the lens and cornea until postnatal day 21, when anterior subcapsular cataracts, sporadic thickening of the corneal stroma, and thinning of the corneal epithelium were noted (Srinivasan et al., 1998). To examine the effects of higher concentrations of TGF-beta1 on the lens and cornea, we constructed transgenic mice harboring the strong, lens… CONTINUE READING

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