Disruption of androgen regulation in the prostate by the environmental contaminant hexachlorobenzene.

  title={Disruption of androgen regulation in the prostate by the environmental contaminant hexachlorobenzene.},
  author={Jody L Ralph and Marie-Claire Orgebin-Crist and Jean-Jacques Lareyre and Colleen C. Nelson},
  journal={Environmental Health Perspectives},
  pages={461 - 466}
Hexachlorobenzene (HCB) is a persistent environmental contaminant that has the potential to interfere with steroid hormone regulation. The prostate requires precise control by androgens to regulate its growth and function. To determine if HCB impacts androgen action in the prostate, we used a number of methods. Our in vitro cell-culture-based assay used a firefly luciferase reporter gene driven by an androgen-responsive promoter. In the presence of dihydrotestosterone, low concentrations (0.5-5… CONTINUE READING


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