Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention.

@article{Johnson2010DisruptionOA,
  title={Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention.},
  author={Jeremy J Johnson and Deeba N Syed and Yewseok Suh and Chenelle R. Heren and Mohammad Saleem and Imtiaz Ahmad Siddiqui and Hasan Mukhtar},
  journal={Cancer prevention research},
  year={2010},
  volume={3 9},
  pages={1112-23}
}
Emerging data are suggesting that estrogens, in addition to androgens, may also be contributing to the development of prostate cancer (PCa). In view of this notion, agents that target estrogens, in addition to androgens, may be a novel approach for PCa chemoprevention and treatment. Thus, the identification and development of nontoxic dietary agents capable of disrupting androgen receptor (AR) in addition to estrogen receptor (ER) could be extremely useful in the management of PCa. Through… CONTINUE READING