Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice

@article{Cleary2001DisruptionOA,
  title={Disruption of an imprinted gene cluster by a targeted chromosomal translocation in mice},
  author={Michele A. Cleary and Catherine D. van Raamsdonk and John Levorse and Binhai Zheng and Allan Bradley and Shirley M. Tilghman},
  journal={Nature Genetics},
  year={2001},
  volume={29},
  pages={78-82}
}
Genomic imprinting is an epigenetic process in which the activity of a gene is determined by its parent of origin. Mechanisms governing genomic imprinting are just beginning to be understood. However, the tendency of imprinted genes to exist in chromosomal clusters suggests a sharing of regulatory elements. To better understand imprinted gene clustering, we disrupted a cluster of imprinted genes on mouse distal chromosome 7 using the Cre/loxP recombination system. In mice carrying a site… CONTINUE READING