Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.

@article{Das2006DisruptionOA,
  title={Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.},
  author={Amitava Das and Martin E Fernandez-Zapico and Sheng Cao and Janet Z. Yao and Stefano Fiorucci and Robert P. Hebbel and Raul A Urrutia and Vijay H Shah},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 51},
  pages={39105-13}
}
The farnesoid X receptor (FXR) signaling pathway regulates bile acid and cholesterol homeostasis. Here, we demonstrate, using a variety of gain- and loss-of-function approaches, a role of FXR in the process of cell motility, which involves the small heterodimeric partner (SHP)-dependent up-regulation of matrix metalloproteinase-9. We use this observation to reveal a transcriptional regulatory mechanism involving the SP/KLF transcription factors, SP2 and KLF6. Small interference RNA-based… CONTINUE READING