Disruption of an M. tuberculosis Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice

@inproceedings{Goodsmith2015DisruptionOA,
  title={Disruption of an M. tuberculosis Membrane Protein Causes a Magnesium-dependent Cell Division Defect and Failure to Persist in Mice},
  author={Nichole I Goodsmith and Xinzheng V. Guo and Omar H. Vandal and Julien Vaubourgeix and Ruojun Wang and H{\'e}l{\`e}ne Botella and Shuang Song and Kamlesh Kumar Bhatt and Amir Liba and Padmini Salgame and Dirk Schnappinger and Sabine Ehrt and Marcel A. Behr},
  booktitle={PLoS pathogens},
  year={2015}
}
The identification of Mycobacterium tuberculosis genes necessary for persistence in vivo provides insight into bacterial biology as well as host defense strategies. We show that disruption of M. tuberculosis membrane protein PerM (Rv0955) resulted in an IFN-γ-dependent persistence defect in chronic mouse infection despite the mutant's near normal growth during acute infection. The perM mutant required increased magnesium for replication and survival; incubation in low magnesium media resulted… CONTINUE READING
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