Disruption of actin cytoskeleton attenuates sulfonylurea inhibition of cardiac ATP-sensitive K+ channels

@article{Yokoshiki1997DisruptionOA,
  title={Disruption of actin cytoskeleton attenuates sulfonylurea inhibition of cardiac ATP-sensitive K+ channels},
  author={Hisashi Yokoshiki and Yasuhiro Katsube and Masanori Sunagawa and Takashi Seki and Nicholas Sperelakis},
  journal={Pfl{\"u}gers Archiv},
  year={1997},
  volume={434},
  pages={203-205}
}
 Two actin filament-depolymerizing agents, DNase I and cytochalasin D, were used to examine the involvement of the cytoskeleton in the functional interaction between the sulfonylurea receptor (SUR) and the ATP-sensitive K+ (KATP) channels. Isolated rat ventricular cardiomyocytes were studied using open cell-attached patches for single-channel recording. Bath application of DNase I (100 μg/ml) or cytochalasin D (10 μM) stimulated the KATP channel activities (in presence of 30 μM ATP), and these… CONTINUE READING
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Recon - stitution of IKATP : An inward rectifier subunit plus the sulfonylurea receptor

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