Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.

@article{Castilho2015DisruptionOA,
  title={Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.},
  author={Aurea Castilho and Ant{\'o}nio Francisco Ambr{\'o}sio and Espen Hartveit and Margaret Lin Veruki},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 13},
  pages={5422-33}
}
Diabetes leads to dysfunction of the neural retina before and independent of classical microvascular diabetic retinopathy, but previous studies have failed to demonstrate which neurons and circuits are affected at the earliest stages. Here, using patch-clamp recording and two-photon Ca(2+) imaging in rat retinal slices, we investigated diabetes-evoked changes in a microcircuit consisting of rod bipolar cells and their dyad postsynaptic targets, AII and A17 amacrine cells, which play an… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
9 Citations
65 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Distributed parallel processing in retinal amacrine cells

  • JS Diamond, WN Grimes
  • The computing dendrite : from structure to…
  • 2014
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…