Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.

@article{Rachdi2008DisruptionOT,
  title={Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.},
  author={Latif Rachdi and Norman Balcazar and Fernando Osorio-Duque and Lynda Elghazi and Aaron Weiss and Aaron P. Gould and Karen J Chang-Chen and Michael J Gambello and Ernesto Bernal-Mizrachi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 27},
  pages={
          9250-5
        }
}
  • Latif Rachdi, Norman Balcazar, +6 authors Ernesto Bernal-Mizrachi
  • Published in
    Proceedings of the National…
    2008
  • Biology, Medicine
  • Regulation of pancreatic beta cell mass and function is a major determinant for the development of diabetes. Growth factors and nutrients are important regulators of beta cell mass and function. The signaling pathways by which these growth signals modulate these processes have not been completely elucidated. Tsc2 is an attractive candidate to modulate these processes, because it is a converging point for growth factor and nutrient signals. In these experiments, we generated mice with… CONTINUE READING

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