Disruption of TGFbeta signaling pathways in human pancreatic cancer cells.

@article{Simeone2000DisruptionOT,
  title={Disruption of TGFbeta signaling pathways in human pancreatic cancer cells.},
  author={Diane M Simeone and T. Pham and Craig D. Logsdon},
  journal={Annals of surgery},
  year={2000},
  volume={232 1},
  pages={73-80}
}
OBJECTIVE To investigate whether transforming growth factor beta (TGFbeta) signaling is disrupted in human pancreatic cancer cells, and to study the role of TGFbeta receptors and Smad genes. SUMMARY BACKGROUND DATA TGFbeta is a known inhibitor of pancreatic growth. Disruption of the TGFbeta signaling pathway may play a role in pancreatic cancer development. METHODS The effect of TGFbeta on the BxPC-3, MiaPaCa-2, and PANC-1 pancreatic cancer cell lines was evaluated by [3H]thymidine… CONTINUE READING

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