Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade.

  title={Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade.},
  author={Christian Pallasch and Sabine Ulbrich and Reinhild Brinker and Michael J Hallek and Robert A Uger and C M Wendtner},
  journal={Leukemia research},
  volume={33 3},
CD200 plays a key role in regulating the immune system and has been shown to be upregulated on the surface of different tumors including chronic lymphocytic leukemia. In this study we addressed the effects of CD200 over-expression in CLL cells on autologous T cells in a mixed lymphocyte reaction system. We used native and CD40 ligand (CD40L)-stimulated CLL cells as antigen-presenting cells (APCs) to expand autologous T cells of 14 patients. T cell proliferation over 3 weeks of in vitro culture… CONTINUE READING

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