Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

  title={Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis},
  author={Beatrice Grabner and Daniel Schramek and Kristina M. Mueller and Herwig P Moll and Jasmin Svinka and Thomas Hoffmann and Eva Bauer and Leander Blaas and Natascha Hruschka and Katalin Zboray and Patricia Stiedl and Harini Nivarthi and Edith Bogner and Wolfgang Gruber and Thomas Mohr and Ralf H. Zwick and Lukas Kenner and Valeria Poli and Fritz Aberger and Dagmar Stoiber and Gerda Egger and Harald Esterbauer and Johannes Zuber and Richard Moriggl and Robert Eferl and Bal{\'a}zs Győrffy and Josef M. Penninger and Helmut H Popper and Emilio Casanova},
  booktitle={Nature communications},
STAT3 is considered to play an oncogenic role in several malignancies including lung cancer; consequently, targeting STAT3 is currently proposed as therapeutic intervention. Here we demonstrate that STAT3 plays an unexpected tumour-suppressive role in KRAS mutant lung adenocarcinoma (AC). Indeed, lung tissue-specific inactivation of Stat3 in mice results in increased Kras(G12D)-driven AC initiation and malignant progression leading to markedly reduced survival. Knockdown of STAT3 in xenografted… CONTINUE READING
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