Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell–cell adhesion complexes

@article{Rivat2004DisruptionOS,
  title={Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell–cell adhesion complexes},
  author={Christine Rivat and Olivier de Wever and Erik A. Bruyneel and Marc De Mareel and Christian P Gespach and Samir Attoub},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={3317-3327}
}
STAT3 is frequently overexpressed and constitutively activated by tyrosine phosphorylation during malignant transformation. Despite the clear importance of STAT3 in cell proliferation and survival in diverse human cancers, its possible contribution to tumor cell adhesion, motility and invasion remains hypothetical. We therefore compared the transforming properties of STAT3wt, its constitutively activated dimeric form STAT3C, and the dominant negative mutant STAT3-Y705F in human colorectal HCT8… CONTINUE READING
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