Disruption of Rac1 signaling reduces ischemia-reperfusion injury in the diabetic heart by inhibiting calpain.

Abstract

Diabetes increases myocardial ischemia/reperfusion (I/R) injury. However, the underlying mechanisms remain incompletely understood. This study investigated the role of Rac1 signaling and calpain in exacerbated I/R injury in diabetic hearts. Mice with cardiac-specific deletion of Rac1 (Rac1-ko) and transgenic mice with cardiac-specific superoxide dismutase-2… (More)
DOI: 10.1016/j.freeradbiomed.2010.09.018

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@article{Shan2010DisruptionOR, title={Disruption of Rac1 signaling reduces ischemia-reperfusion injury in the diabetic heart by inhibiting calpain.}, author={Limei Shan and Jianmin Li and Meng Wei and Jian Ma and Li Wan and Wei Zhu and Ying Li and Huaqing Zhu and J. Malcolm O. Arnold and T Peng}, journal={Free radical biology & medicine}, year={2010}, volume={49 11}, pages={1804-14} }