Disruption of Rac1 signaling reduces ischemia-reperfusion injury in the diabetic heart by inhibiting calpain.

@article{Shan2010DisruptionOR,
  title={Disruption of Rac1 signaling reduces ischemia-reperfusion injury in the diabetic heart by inhibiting calpain.},
  author={Limei Shan and Jianmin Li and Meng Wei and Junfeng Ma and Li Wan and Wei Zhu and Ying Li and Huaqing Zhu and J. Malcolm O. Arnold and Tianqing Peng},
  journal={Free radical biology & medicine},
  year={2010},
  volume={49 11},
  pages={
          1804-14
        }
}
Diabetes increases myocardial ischemia/reperfusion (I/R) injury. However, the underlying mechanisms remain incompletely understood. This study investigated the role of Rac1 signaling and calpain in exacerbated I/R injury in diabetic hearts. Mice with cardiac-specific deletion of Rac1 (Rac1-ko) and transgenic mice with cardiac-specific superoxide dismutase-2 (SOD2) or calpastatin overexpression were rendered diabetic with streptozotocin. Isolated perfused hearts were subjected to global I/R… CONTINUE READING
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