Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.

@article{Miller2012DisruptionON,
  title={Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.},
  author={Corey J. Miller and Sellamuthu Subbanna Gounder and Sankaranarayanan Kannan and Karan Goutam and Vasanthi R Muthusamy and Matthew A Firpo and J. David Symons and Robert Paine and John R. Hoidal and Namakkal Soorappan Rajasekaran},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1822 6},
  pages={1038-50}
}
Age-associated decline in antioxidant potential and accumulation of reactive oxygen/nitrogen species are primary causes for multiple health problems, including muscular dystrophy and sarcopenia. The role of the nuclear erythroid-2-p45-related factor-2 (Nrf2) signaling has been implicated in antioxidant gene regulation. Here, we investigated the loss-of-function mechanisms for age-dependent regulation of Nrf2/ARE (Antioxidant Response Element) signaling in skeletal muscle (SM). Under basal… CONTINUE READING