Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice.

@article{Dill2012DisruptionON,
  title={Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice.},
  author={Michael T. Dill and Sonja Rothweiler and Valentin Djonov and Ruslan Hlushchuk and Luigi Tornillo and Luigi Maria Terracciano and Silvia Meili-Butz and Freddy Radtke and Markus H Heim and David Semela},
  journal={Gastroenterology},
  year={2012},
  volume={142 4},
  pages={967-977.e2}
}
BACKGROUND & AIMS Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs). METHODS We studied MxCre Notch1(lox/lox) mice (conditional knockout mice without tissue-specific… CONTINUE READING
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