Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity.

@article{Lee2006DisruptionON,
  title={Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity.},
  author={Soohyun Lee and Paul A. Dawson and Amitha K. Hewavitharana and P. N. Shaw and Daniel Markovich},
  journal={Hepatology},
  year={2006},
  volume={43 6},
  pages={1241-7}
}
Sulfate is required for detoxification of xenobiotics such as acetaminophen (APAP), a leading cause of liver failure in humans. The NaS1 sulfate transporter maintains blood sulfate levels sufficiently high for sulfonation reactions to work effectively for drug detoxification. In the present study, we identified two loss-of-function polymorphisms in the human NaS1 gene and showed the Nas1-null mouse to be hypersensitive to APAP hepatotoxicity. APAP treatment led to increased liver damage and… CONTINUE READING
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