Disruption of Microtubule Network Rescues Aberrant Actin Comets in Dynamin2-Depleted Cells

@inproceedings{Henmi2011DisruptionOM,
  title={Disruption of Microtubule Network Rescues Aberrant Actin Comets in Dynamin2-Depleted Cells},
  author={Yuji Henmi and Kenji Tanabe and Kohji Takei},
  booktitle={PloS one},
  year={2011}
}
A large GTPase dynamin, which is required for endocytic vesicle formation, regulates the actin cytoskeleton through its interaction with cortactin. Dynamin2 mutants impair the formation of actin comets, which are induced by Listeria monocytogenes or phosphatidylinositol-4-phosphate 5-kinase. However, the role of dynamin2 in the regulation of the actin comet is still unclear. Here we show that aberrant actin comets in dynamin2-depleted cells were rescued by disrupting of microtubule networks… CONTINUE READING
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