Disruption of Large-Scale Brain Systems in Advanced Aging

@article{AndrewsHanna2007DisruptionOL,
  title={Disruption of Large-Scale Brain Systems in Advanced Aging},
  author={Jessica R. Andrews-Hanna and Abraham Z. Snyder and Justin L. Vincent and Cindy Lustig and D. Head and Marcus E. Raichle and Randy L. Buckner},
  journal={Neuron},
  year={2007},
  volume={56},
  pages={924-935}
}
Cognitive decline is commonly observed in advanced aging even in the absence of disease. Here we explore the possibility that normal aging is accompanied by disruptive alterations in the coordination of large-scale brain systems that support high-level cognition. In 93 adults aged 18 to 93, we demonstrate that aging is characterized by marked reductions in normally present functional correlations within two higher-order brain systems. Anterior to posterior components within the default network… CONTINUE READING
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