Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression.

@article{Beer2015DisruptionOI,
  title={Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression.},
  author={Philip A. Beer and David J H F Knapp and Paul H. Miller and Nagarajan Kannan and Ivan Sloma and Kathy Heel and Sonja Babovic and Elizabeth Bulaeva and Gabrielle M. Rabu and Jefferson Terry and Brian J. Druker and Marc M. Loriaux and Keith R. Loeb and Jerald P Radich and Wendy Naomi Erber and Connie J. Eaves},
  journal={Blood},
  year={2015},
  volume={125 3},
  pages={504-15}
}
Without effective therapy, chronic-phase chronic myeloid leukemia (CP-CML) evolves into an acute leukemia (blast crisis [BC]) that displays either myeloid or B-lymphoid characteristics. This transition is often preceded by a clinically recognized, but biologically poorly characterized, accelerated phase (AP). Here, we report that IKAROS protein is absent or reduced in bone marrow blasts from most CML patients with advanced myeloid disease (AP or BC). This contrasts with primitive CP-CML cells… CONTINUE READING
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Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP 98 HOXA 10 homeodomain fusion gene

  • I Sloma, S Imren, PA Beer
  • Leukemia
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