Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus.

@article{Du2010DisruptionOH,
  title={Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus.},
  author={Te Du and Guoying Zhou and Shaniya H. Khan and Haidong Gu and Bernard Roizman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 36},
  pages={15904-9}
}
In nonneuronal cells, herpes simplex virus 1 overcomes host defenses, replicates, and ultimately kills the infected cell. Among the host defenses suppressed by the virus is a repressor complex whose key components are histone deacetylase (HDAC) 1 or 2, RE-1 silencing transcription factor (REST), corepressor of REST (CoREST), and lysine-specific demethylase (LSD) 1. In neurons innervating cells at the portal of entry into the body, the virus establishes a "latent" infection in which viral DNA is… CONTINUE READING

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